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Scientific References

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The Biological Effects of Silicone Gel Sheeting.pdf
(4pgs. 300kb)
From the Division of Plastic and Reconstructive Surgery, St. M. Annunaiata Hospital, Florence, Italy.

Aesthetic Plast Surg. 2008 Jan;32(1):82-92. Epub 2007 Oct 30.
Evolution of silicone therapy and mechanism of action in scar management.
Mustoe TA.
Division of Plastic Surgery, Northwestern University School of Medicine, 675 North Street Clair 19-250, Chicago, IL 60611, USA. tmustoe@nmh.org
Silicone-based products are widely used in the management of hypertrophic scarring and keloids. This review discusses the range of products available and the clinical evidence of their efficacy in preventing excessive scarring and improving established scars. Silicone gel sheeting has been used successfully for more than 20 years in scar management. A new formulation of silicone gel applied from a tube forms a thin flexible sheet over the newly epithelialized wound or more mature scar. Results from clinical trials and clinical experience suggest that silicone gel is equivalent in efficacy to traditional silicone gel sheeting but easier to use. The mechanism of action of silicone therapy has not been completely determined but is likely to involve occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts.
J Am Acad Dermatol. 2006 Dec;55(6):1024-31. Epub 2006 Sep 18.


Topical treatments for hypertrophic scars.
Zurada JM, Kriegel D, Davis IC.
Columbia University College of Physicians and Surgeons, New York, New York, USA.
Hypertrophic scars represent an abnormal, exaggerated healing response after skin injury. In addition to cosmetic concern, scars may cause pain, pruritus, contractures, and other functional impairments. Therapeutic modalities include topical medications, intralesional corticosteroids, laser therapy, and cryosurgery. Topical therapies, in particular, have become increasingly popular because of their ease of use, comfort, noninvasiveness, and relatively low cost. This review will discuss the properties and effectiveness of these agents, including pressure therapy, silicone gel sheeting and ointment, polyurethane dressing, onion extract, imiquimod 5% cream, and vitamins A and E in the prevention and treatment of hypertrophic scars.
PMID: 17097399 [PubMed - indexed for MEDLINE]
1: Ann Ital Chir. 2005 Jan-Feb;76(1):79-83.


[Silicone occlusive sheeting vs silicone cushion for the treatment of hypertrophic and keloid scars. A prospective-randomized study]
[Article in Italian]
Amicucci G, Schietroma M, Rossi M, Mazzotta C.
Dipartimento di Scienze Chirurgiche Università degli Studi di L'Aquila.
BACKGROUND: Silicone gel and silicone occlusive sheeting are widely used at present for the treatment of hypertrophic and keloid scars. In recent studies the possibility was raised that static electricity generated by friction activated silicone sheeting could be the reason for this effect, and that it can, with time, cause involution of hypertrophic and keloid scars. Objective of this study was to test this hypothesis and to observe weather a continuous and also an increased negatively charged static electric field will shorten the treatment period. A silicone cushion was developed with the purpose of increasing a negative static-electric charge to accelerate the regression process. METHODS: From November 2001 to June 2002 we studied in a prospective randomized study, 72 patients with hypertrophic an keloid scars. The trial extended over a 8-month period. 37 patients underwent silicone occlusive sheeting, the remaining 35 patients underwent silicone cushion (Clinicel). RESULTS: Treatment with the silicone cushions yielded 74,2% cessation of itching and burning followed by pallor and flattening of the scar, some markedly so, over a few weeks to 5 months period. Additional 25,7% had their scars resolved in up to 8 months of treatment. Four patients (11,4%) who add recalcitrant scars with little response to the use of the silicone cushion were given intralesional corticosteroid injections, in addiction to the use of the cushion, resulting in a fairly rayed resolution of these scars over a period of 2 months. Treatment with the silicone occlusive sheeting yielded 52,3% itching and burning cessation followed by pallor and flattening of the scar, some markedly so, over a few weeks to 5 months period. Additional 22,1% had their scars resolved in up to 8 months of treatment. In conclusion by comparing the results of this trial using silicone cushions for the treatment of hypertrophic and keloid scars with those obtained using silicone gel or occlusive sheeting, a much faster response was demonstrated.
 
 
 
 
1: Plast Surg Nurs. 2006 Apr-Jun;26(2):87-92.
Influence of silicone on abnormal scarring.
Fette A.
Wound Healing and Tissue Repair from the WHRU, University of Cardiff, Wales. andreas.fette@gmx.de
The problem of scarring represents a large area of an unmet medical need, since people with abnormal skin scarring may face physical and psychological consequences that may be associated with substantial emotional and financial costs. To date, treatment options are to leave the scar alone or use invasive or noninvasive management. Silicone is the key in noninvasive management, with the following overall results reported: great improvement of the scar appearance, easy to apply, painless, and almost free of side effects. When analyzing all presented results in this research sample, it becomes obvious that they are mainly based on subjective, not well-defined scar assessment by the individual without comparison to controls or rating against validated scores and therefore lacking real scientific or evidence-based criteria.
PMID: 16783182 [PubMed - indexed for MEDLINE]

 
   
   
 

 
 
                 

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